Solute-Solvent Interactions From Gas Chromatographic Activity Coefficients and the Solvation Parameter Model for Nitrogen-Containing Stationary Phases
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چکیده
منابع مشابه
Solvation of diclofenac in water from atomistic molecular dynamics simulations - interplay between solute-solute and solute-solvent interactions.
The solubility-permeability relationship of active pharmaceutical ingredients determines the efficacy of their usage. Diclofenac (DCL), which is a widely used nonsteroidal anti-inflammatory drug, is characterized by extremely good membrane permeability, but low water solubility limiting drug effectiveness. The present research focuses on the fundamental explanation of this limitation using the ...
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ژورنال
عنوان ژورنال: Journal of Chromatographic Science
سال: 2003
ISSN: 0021-9665,1945-239X
DOI: 10.1093/chromsci/41.4.215